Lyon made it nine games unbeaten and moved into second place in the French Ligue 1 after a convincing 3-0 home victory over 10-man Reims.
Lille only need a draw at struggling Saint-Etienne later on Sunday to move back into second and can move level on points with leaders Paris Saint-Germain if they win.
Forward Karl Toko Ekambi put the Lyon ahead in the 21st minute when he volleyed in Memphis Depay’s brilliant cross from the left.
Reims midfielder Moreto Cassama was then sent off 10 minutes later for fouling Depay as he was running through on goal.
Lyon had a second goal ruled out shortly after when striker Tino Kadewere was given offside.
Kadewere and Toko Ekambi also hit the post in a one-sided first half, and the inevitable second goal came soon after the break when Ekambi set up midfielder Bruno Guimaraes.
The day got even better for Lyon when Moussa Dembele netted his first of the season, latching onto Ekambi’s pass and expertly dinking the ball over the goalie in the 81st.
Champions PSG’s 2-2 draw at home to Bordeaux on Saturday has opened the door for their challengers.